{"id":269,"date":"2026-08-24T12:51:27","date_gmt":"2026-08-24T12:51:27","guid":{"rendered":"https:\/\/gmbay.com.tr\/yeni\/?page_id=269"},"modified":"2026-09-26T11:04:34","modified_gmt":"2026-09-26T11:04:34","slug":"itraxyl-2","status":"publish","type":"page","link":"https:\/\/gmbay.com.tr\/en\/itraxyl-2\/","title":{"rendered":"Itraxyl"},"content":{"rendered":"\n<!-- TAILWIND VE MARKA RENK MOTORU -->\n<script src=\"https:\/\/cdn.tailwindcss.com\"><\/script>\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Inter:wght@300;400;500;600;700&amp;family=Manrope:wght@600;700;800&amp;display=swap\" rel=\"stylesheet\">\n<script>\n    tailwind.config = {\n        theme: {\n            extend: {\n                colors: {\n                    'brand-green': '#8bb745',\n                    'brand-green2': '#76a035',\n                    'brand-blue': '#064f99',\n                    'brand-dark': '#1e293b',\n                    'brand-muted': '#64748b',\n                    'brand-light': '#f8fafc',\n                },\n                fontFamily: {\n                    inter: ['Inter', 'sans-serif'],\n                    manrope: ['Manrope', 'sans-serif'],\n                }\n            }\n        }\n    }\n<\/script>\n\n<!-- ==================== GMBAY RESPONSIVE HEADER \/ \u00dcST MEN\u00dc ==================== -->\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin=\"\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Inter:wght@400;500;600;700&amp;display=swap\" rel=\"stylesheet\">\n\n<style>\n    .gmbay-header-wrapper {\n        font-family: 'Inter', -apple-system, BlinkMacSystemFont, \"Segoe UI\", Roboto, sans-serif;\n        box-sizing: border-box;\n        width: 100%;\n    }\n    .gmbay-header-wrapper * {\n        box-sizing: border-box;\n    }\n\n    .gmbay-header {\n        width: 100%;\n        background-color: rgba(255, 255, 255, 0.98);\n        backdrop-filter: blur(8px);\n        border-bottom: 1px solid #e2e8f0;\n        position: sticky;\n        top: 0;\n        z-index: 99999;\n        box-shadow: 0 2px 10px rgba(0, 0, 0, 0.04);\n    }\n\n    .gmbay-container {\n        max-width: 1280px;\n        margin: 0 auto;\n        padding: 0.4rem 1.5rem;\n        display: flex;\n        justify-content: space-between;\n        align-items: center;\n    }\n\n    \/* Logo *\/\n    .gmbay-logo-link {\n        display: flex;\n        align-items: center;\n        text-decoration: none !important;\n        outline: none !important;\n    }\n    .gmbay-logo-img {\n        height: 95px;\n        width: auto;\n        max-width: 320px;\n        object-fit: contain;\n        transition: opacity 0.2s ease;\n        display: block;\n    }\n    .gmbay-logo-link:hover .gmbay-logo-img {\n        opacity: 0.9;\n    }\n\n    \/* Masa\u00fcst\u00fc Navigasyon *\/\n    .gmbay-desktop-nav {\n        display: flex;\n        align-items: center;\n        gap: 1.75rem;\n        margin: 0;\n        padding: 0;\n        list-style: none;\n    }\n\n    .gmbay-nav-item {\n        position: relative;\n        display: flex;\n        align-items: center;\n        height: 50px;\n    }\n\n    .gmbay-nav-link {\n        color: #1e293b !important;\n        font-size: 0.925rem;\n        font-weight: 600;\n        text-decoration: none !important;\n        display: inline-flex;\n        align-items: center;\n        gap: 0.35rem;\n        position: relative;\n        padding: 6px 0;\n        background: transparent !important;\n        border: none !important;\n        outline: none !important;\n        cursor: pointer;\n        transition: color 0.2s ease;\n    }\n\n    .gmbay-nav-link::after {\n        content: '';\n        position: absolute;\n        width: 100%;\n        height: 2.5px;\n        bottom: 0;\n        left: 0;\n        background-color: #8bb745;\n        transform: scaleX(0);\n        transform-origin: bottom center;\n        transition: transform 0.25s ease-out;\n        border-radius: 2px;\n    }\n    .gmbay-nav-link:hover,\n    .gmbay-nav-item:hover > .gmbay-nav-link {\n        color: #8bb745 !important;\n    }\n    .gmbay-nav-link:hover::after,\n    .gmbay-nav-item:hover > .gmbay-nav-link::after {\n        transform: scaleX(1);\n    }\n\n    \/* Masa\u00fcst\u00fc A\u00e7\u0131l\u0131r Men\u00fc *\/\n    .gmbay-dropdown {\n        position: absolute;\n        top: 100%;\n        left: 0;\n        min-width: 290px;\n        background: #ffffff;\n        border-radius: 12px;\n        box-shadow: 0 12px 28px rgba(0, 0, 0, 0.1);\n        border-top: 3px solid #8bb745;\n        padding: 0.5rem 0;\n        opacity: 0;\n        visibility: hidden;\n        transform: translateY(10px);\n        transition: all 0.2s ease;\n        z-index: 1000;\n    }\n\n    .gmbay-nav-item:hover .gmbay-dropdown {\n        opacity: 1;\n        visibility: visible;\n        transform: translateY(0);\n    }\n\n    .gmbay-dropdown-link {\n        display: block;\n        padding: 0.7rem 1.25rem;\n        color: #475569 !important;\n        font-size: 0.875rem;\n        font-weight: 500;\n        text-decoration: none !important;\n        transition: all 0.2s ease;\n        white-space: nowrap;\n    }\n    .gmbay-dropdown-link:hover {\n        background-color: #f8fafc;\n        color: #8bb745 !important;\n        padding-left: 1.5rem;\n    }\n\n    \/* Sa\u011f Taraf Aksiyon Alan\u0131 (Bize Ula\u015f\u0131n ve Dil Butonu Yan Yana) *\/\n    .gmbay-actions {\n        display: flex;\n        align-items: center;\n        gap: 0.75rem;\n    }\n\n    \/* Bize Ula\u015f\u0131n Butonu *\/\n    .gmbay-cta-btn {\n        background-color: #8bb745 !important;\n        color: #ffffff !important;\n        font-size: 0.8rem;\n        font-weight: 700;\n        text-transform: uppercase;\n        letter-spacing: 0.05em;\n        padding: 0 1.35rem;\n        height: 42px;\n        border-radius: 8px;\n        text-decoration: none !important;\n        display: inline-flex;\n        align-items: center;\n        justify-content: center;\n        transition: all 0.2s ease;\n        box-shadow: 0 2px 6px rgba(139, 183, 69, 0.25);\n        border: 2px solid #8bb745 !important;\n        box-sizing: border-box;\n    }\n    .gmbay-cta-btn:hover {\n        background-color: #79a239 !important;\n        border-color: #79a239 !important;\n        transform: translateY(-1px);\n        box-shadow: 0 4px 12px rgba(139, 183, 69, 0.35);\n    }\n\n    \/* Mobil Hamburger Buton *\/\n    .gmbay-hamburger {\n        display: none;\n        flex-direction: column;\n        justify-content: center;\n        gap: 5px;\n        width: 40px;\n        height: 40px;\n        background: transparent;\n        border: none;\n        cursor: pointer;\n        padding: 0;\n        z-index: 100001;\n    }\n    .gmbay-hamburger span {\n        display: block;\n        width: 26px;\n        height: 2.5px;\n        background-color: #1e293b;\n        border-radius: 2px;\n        transition: all 0.3s ease;\n    }\n    .gmbay-hamburger.is-active span:nth-child(1) {\n        transform: translateY(7.5px) rotate(45deg);\n        background-color: #8bb745;\n    }\n    .gmbay-hamburger.is-active span:nth-child(2) {\n        opacity: 0;\n    }\n    .gmbay-hamburger.is-active span:nth-child(3) {\n        transform: translateY(-7.5px) rotate(-45deg);\n        background-color: #8bb745;\n    }\n\n    \/* Mobil Men\u00fc \u00c7ekmecesi *\/\n    .gmbay-mobile-menu {\n        display: none;\n        width: 100%;\n        background-color: #ffffff;\n        border-top: 1px solid #f1f5f9;\n        box-shadow: 0 10px 20px rgba(0,0,0,0.08);\n        max-height: 0;\n        overflow: hidden;\n        transition: max-height 0.35s ease-in-out;\n    }\n    .gmbay-mobile-menu.is-open {\n        max-height: 80vh;\n        overflow-y: auto;\n    }\n\n    .gmbay-mobile-list {\n        list-style: none;\n        padding: 1rem 1.5rem 1.75rem 1.5rem;\n        margin: 0;\n        display: flex;\n        flex-direction: column;\n        gap: 0.5rem;\n    }\n\n    .gmbay-mobile-link {\n        display: flex;\n        justify-content: space-between;\n        align-items: center;\n        width: 100%;\n        padding: 0.75rem 0;\n        color: #1e293b !important;\n        font-size: 1rem;\n        font-weight: 600;\n        text-decoration: none !important;\n        border-bottom: 1px solid #f8fafc;\n        background: transparent;\n        border: none;\n        text-align: left;\n        cursor: pointer;\n    }\n    .gmbay-mobile-link:hover {\n        color: #8bb745 !important;\n    }\n\n    \/* Mobil Alt Men\u00fcler *\/\n    .gmbay-mobile-submenu {\n        display: none;\n        list-style: none;\n        padding: 0.25rem 0 0.5rem 1rem;\n        margin: 0;\n        background-color: #f8fafc;\n        border-radius: 8px;\n    }\n    .gmbay-mobile-submenu.sub-open {\n        display: flex;\n        flex-direction: column;\n    }\n    .gmbay-mobile-sublink {\n        display: block;\n        padding: 0.6rem 0.75rem;\n        color: #475569 !important;\n        font-size: 0.9rem;\n        font-weight: 500;\n        text-decoration: none !important;\n    }\n    .gmbay-mobile-sublink:hover {\n        color: #8bb745 !important;\n    }\n\n    .gmbay-mobile-cta {\n        display: block;\n        width: 100%;\n        text-align: center;\n        padding: 0.85rem;\n        background-color: #8bb745 !important;\n        color: #ffffff !important;\n        font-weight: 700;\n        border-radius: 8px;\n        text-decoration: none !important;\n        text-transform: uppercase;\n        font-size: 0.85rem;\n        letter-spacing: 0.05em;\n    }\n\n    \/* Medya Sorgular\u0131 *\/\n    @media (max-width: 992px) {\n        .gmbay-desktop-nav,\n        .gmbay-actions {\n            display: none !important;\n        }\n        .gmbay-hamburger {\n            display: flex;\n        }\n        .gmbay-mobile-menu {\n            display: block;\n        }\n        .gmbay-logo-img {\n            height: 75px;\n        }\n    }\n<\/style>\n\n<div class=\"gmbay-header-wrapper\">\n    <header class=\"gmbay-header\">\n        <div class=\"gmbay-container\">\n            \n            <!-- Logo -->\n            <a href=\"https:\/\/gmbay.com.tr\/\" class=\"gmbay-logo-link\">\n                <img decoding=\"async\" src=\"https:\/\/gmbay.com.tr\/wp-content\/uploads\/2026\/08\/yeni-gmbay-logo.png\" alt=\"GM BAY Sa\u011fl\u0131k \u00dcr\u00fcnleri\" class=\"gmbay-logo-img\">\n            <\/a>\n\n            <!-- Masa\u00fcst\u00fc Men\u00fc -->\n            <nav class=\"gmbay-desktop-nav\">\n                <div class=\"gmbay-nav-item\">\n                    <a href=\"https:\/\/gmbay.com.tr\/\" class=\"gmbay-nav-link\">Ana Sayfa<\/a>\n                <\/div>\n                \n                <div class=\"gmbay-nav-item\">\n                    <button type=\"button\" class=\"gmbay-nav-link\">\n                        Kurumsal \n                        <svg width=\"14\" height=\"14\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#8bb745\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 9l6 6 6-6\"><\/path><\/svg>\n                    <\/button>\n                    <div class=\"gmbay-dropdown\">\n                        <a href=\"https:\/\/gmbay.com.tr\/index.php\/kurumsal\/hakkimizda\/\" class=\"gmbay-dropdown-link\">Hakk\u0131m\u0131zda<\/a>\n                        <a href=\"https:\/\/gmbay.com.tr\/index.php\/kurumsal\/misyonumuz-ve-vizyonumuz\/\" class=\"gmbay-dropdown-link\">Misyonumuz ve Vizyonumuz<\/a>\n                        <a href=\"https:\/\/gmbay.com.tr\/index.php\/kurumsal\/degerlerimiz\/\" class=\"gmbay-dropdown-link\">De\u011ferlerimiz<\/a>\n                    <\/div>\n                <\/div>\n\n                <div class=\"gmbay-nav-item\">\n                    <button type=\"button\" class=\"gmbay-nav-link\">\n                        \u00dcr\u00fcnlerimiz \n                        <svg width=\"14\" height=\"14\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#8bb745\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 9l6 6 6-6\"><\/path><\/svg>\n                    <\/button>\n                    <div class=\"gmbay-dropdown\">\n                        <a href=\"https:\/\/gmbay.com.tr\/index.php\/urunlerimiz\/ilac-grubu\/\" class=\"gmbay-dropdown-link\">\u0130la\u00e7 Grubu<\/a>\n                        <a href=\"https:\/\/gmbay.com.tr\/index.php\/dermatoloji-grubu\/\" class=\"gmbay-dropdown-link\">Dermatoloji Grubu<\/a>\n                    <\/div>\n                <\/div>\n\n                <div class=\"gmbay-nav-item\">\n                    <a href=\"https:\/\/gmbay.com.tr\/index.php\/haberler\/\" class=\"gmbay-nav-link\">Haberler<\/a>\n                <\/div>\n            <\/nav>\n\n            <!-- Masa\u00fcst\u00fc Aksiyon Alan\u0131: \u00d6nce Bize Ula\u015f\u0131n, Sa\u011f\u0131nda Dil Butonu -->\n            <div class=\"gmbay-actions\">\n                <a href=\"https:\/\/gmbay.com.tr\/index.php\/iletisim\/\" class=\"gmbay-cta-btn\">Bize Ula\u015f\u0131n<\/a>\n                <div class=\"gmbay-lang-switcher\">\n                    <div class=\"trp-shortcode-switcher__wrapper\"\r\n     style=\"--bg:#ffffff;--bg-hover:#8bb745;--text:#8bb745;--text-hover:#ffffff;--border:2px solid #8bb745;--border-width:2px;--border-color:#8bb745;--border-radius:8px;--flag-radius:2px;--flag-size:18px;--aspect-ratio:4\/3;--font-size:14px;--transition-duration:0.2s\"\r\n     role=\"group\"\r\n     data-open-mode=\"hover\">\r\n\r\n    \r\n        <!-- ANCHOR (in-flow only; sizing\/borders; inert) -->\r\n        <div class=\"trp-language-switcher trp-ls-dropdown trp-shortcode-switcher trp-shortcode-anchor trp-open-on-hover\"\r\n             aria-hidden=\"true\"\r\n             inert\r\n             data-no-translation>\r\n                <div class=\"trp-current-language-item__wrapper\">\r\n        <a class=\"trp-language-item trp-language-item__default trp-language-item__current\" data-no-translation href=\"https:\/\/gmbay.com.tr\/en\/wp-json\/wp\/v2\/pages\/269#TRPLINKPROCESSED\" title=\"EN\"><span class=\"trp-language-item-name\">EN<\/span><\/a>                    <svg class=\"trp-shortcode-arrow\" width=\"20\" height=\"20\" viewBox=\"0 0 20 21\" fill=\"none\" aria-hidden=\"true\" focusable=\"false\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\r\n                <path d=\"M5 8L10 13L15 8\" stroke=\"var(--text)\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\r\n            <\/svg>\r\n            <\/div>\r\n            <\/div>\r\n\r\n        <!-- OVERLAY (positioned; interactive surface) -->\r\n        <div class=\"trp-language-switcher trp-ls-dropdown trp-shortcode-switcher trp-shortcode-overlay trp-open-on-hover\"\r\n             role=\"navigation\"\r\n             aria-label=\"Website language selector\"\r\n             data-no-translation\r\n        >\r\n                <div class=\"trp-current-language-item__wrapper\">\r\n        <div class=\"trp-language-item trp-language-item__default trp-language-item__current\" data-no-translation role=\"button\" aria-expanded=\"false\" tabindex=\"0\" aria-label=\"Change language\" aria-controls=\"trp-shortcode-dropdown-6ac2ee6d8e2df\"><span class=\"trp-language-item-name\">EN<\/span><\/div>                    <svg class=\"trp-shortcode-arrow\" width=\"20\" height=\"20\" viewBox=\"0 0 20 21\" fill=\"none\" aria-hidden=\"true\" focusable=\"false\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\r\n                <path d=\"M5 8L10 13L15 8\" stroke=\"var(--text)\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\r\n            <\/svg>\r\n            <\/div>\r\n    \r\n            <div class=\"trp-switcher-dropdown-list\"\r\n                 id=\"trp-shortcode-dropdown-6ac2ee6d8e2df\"\r\n                 role=\"group\"\r\n                 aria-label=\"Available languages\"\r\n                 hidden\r\n                 inert\r\n            >\r\n                                                            <a class=\"trp-language-item\" href=\"https:\/\/gmbay.com.tr\/en\/wp-json\/wp\/v2\/pages\/269#TRPLINKPROCESSED\" title=\"TR\">\r\n                                                                                        <span class=\"trp-language-item-name\" data-no-translation>TR<\/span>\r\n                                                                                <\/a>\r\n                                                <\/div>\r\n        <\/div>\r\n\r\n    <\/div>\r\n\n                <\/div>\n            <\/div>\n\n            <!-- Mobil Hamburger Buton -->\n            <button class=\"gmbay-hamburger\" id=\"gmbayMenuBtn\" aria-label=\"Men\u00fcy\u00fc A\u00e7\">\n                <span><\/span>\n                <span><\/span>\n                <span><\/span>\n            <\/button>\n\n        <\/div>\n\n        <!-- Mobil Men\u00fc \u00c7ekmecesi -->\n        <div class=\"gmbay-mobile-menu\" id=\"gmbayMobileDrawer\">\n            <ul class=\"gmbay-mobile-list\">\n                <li>\n                    <a href=\"https:\/\/gmbay.com.tr\/\" class=\"gmbay-mobile-link\">Ana Sayfa<\/a>\n                <\/li>\n                \n                <li>\n                    <button type=\"button\" class=\"gmbay-mobile-link\" onclick=\"toggleSubmenu('subKurumsal', this)\">\n                        <span>Kurumsal<\/span>\n                        <svg width=\"16\" height=\"16\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#8bb745\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 9l6 6 6-6\"><\/path><\/svg>\n                    <\/button>\n                    <ul class=\"gmbay-mobile-submenu\" id=\"subKurumsal\">\n                        <li><a href=\"https:\/\/gmbay.com.tr\/index.php\/kurumsal\/hakkimizda\/\" class=\"gmbay-mobile-sublink\">Hakk\u0131m\u0131zda<\/a><\/li>\n                        <li><a href=\"https:\/\/gmbay.com.tr\/index.php\/kurumsal\/misyonumuz-ve-vizyonumuz\/\" class=\"gmbay-mobile-sublink\">Misyonumuz ve Vizyonumuz<\/a><\/li>\n                        <li><a href=\"https:\/\/gmbay.com.tr\/index.php\/kurumsal\/degerlerimiz\/\" class=\"gmbay-mobile-sublink\">De\u011ferlerimiz<\/a><\/li>\n                    <\/ul>\n                <\/li>\n\n                <li>\n                    <button type=\"button\" class=\"gmbay-mobile-link\" onclick=\"toggleSubmenu('subUrunler', this)\">\n                        <span>\u00dcr\u00fcnlerimiz<\/span>\n                        <svg width=\"16\" height=\"16\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#8bb745\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 9l6 6 6-6\"><\/path><\/svg>\n                    <\/button>\n                    <ul class=\"gmbay-mobile-submenu\" id=\"subUrunler\">\n                        <li><a href=\"https:\/\/gmbay.com.tr\/index.php\/urunlerimiz\/ilac-grubu\/\" class=\"gmbay-mobile-sublink\">\u0130la\u00e7 Grubu<\/a><\/li>\n                        <li><a href=\"https:\/\/gmbay.com.tr\/index.php\/dermatoloji-grubu\/\" class=\"gmbay-mobile-sublink\">Dermatoloji Grubu<\/a><\/li>\n                    <\/ul>\n                <\/li>\n\n                <li>\n                    <a href=\"https:\/\/gmbay.com.tr\/index.php\/haberler\/\" class=\"gmbay-mobile-link\">Haberler<\/a>\n                <\/li>\n\n                <li style=\"display: flex; gap: 0.75rem; align-items: center; margin-top: 1rem;\">\n                    <a href=\"https:\/\/gmbay.com.tr\/index.php\/iletisim\/\" class=\"gmbay-mobile-cta\" style=\"margin-top: 0; flex: 1;\">Bize Ula\u015f\u0131n<\/a>\n                    <div class=\"gmbay-lang-switcher\" style=\"flex: 0 0 auto;\">\n                        <div class=\"trp-shortcode-switcher__wrapper\"\r\n     style=\"--bg:#ffffff;--bg-hover:#8bb745;--text:#8bb745;--text-hover:#ffffff;--border:2px solid #8bb745;--border-width:2px;--border-color:#8bb745;--border-radius:8px;--flag-radius:2px;--flag-size:18px;--aspect-ratio:4\/3;--font-size:14px;--transition-duration:0.2s\"\r\n     role=\"group\"\r\n     data-open-mode=\"hover\">\r\n\r\n    \r\n        <!-- ANCHOR (in-flow only; sizing\/borders; inert) -->\r\n        <div class=\"trp-language-switcher trp-ls-dropdown trp-shortcode-switcher trp-shortcode-anchor trp-open-on-hover\"\r\n             aria-hidden=\"true\"\r\n             inert\r\n             data-no-translation>\r\n                <div class=\"trp-current-language-item__wrapper\">\r\n        <a class=\"trp-language-item trp-language-item__default trp-language-item__current\" data-no-translation href=\"https:\/\/gmbay.com.tr\/en\/wp-json\/wp\/v2\/pages\/269#TRPLINKPROCESSED\" title=\"EN\"><span class=\"trp-language-item-name\">EN<\/span><\/a>                    <svg class=\"trp-shortcode-arrow\" width=\"20\" height=\"20\" viewBox=\"0 0 20 21\" fill=\"none\" aria-hidden=\"true\" focusable=\"false\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\r\n                <path d=\"M5 8L10 13L15 8\" stroke=\"var(--text)\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\r\n            <\/svg>\r\n            <\/div>\r\n            <\/div>\r\n\r\n        <!-- OVERLAY (positioned; interactive surface) -->\r\n        <div class=\"trp-language-switcher trp-ls-dropdown trp-shortcode-switcher trp-shortcode-overlay trp-open-on-hover\"\r\n             role=\"navigation\"\r\n             aria-label=\"Website language selector\"\r\n             data-no-translation\r\n        >\r\n                <div class=\"trp-current-language-item__wrapper\">\r\n        <div class=\"trp-language-item trp-language-item__default trp-language-item__current\" data-no-translation role=\"button\" aria-expanded=\"false\" tabindex=\"0\" aria-label=\"Change language\" aria-controls=\"trp-shortcode-dropdown-6ac2ee6d8f28a\"><span class=\"trp-language-item-name\">EN<\/span><\/div>                    <svg class=\"trp-shortcode-arrow\" width=\"20\" height=\"20\" viewBox=\"0 0 20 21\" fill=\"none\" aria-hidden=\"true\" focusable=\"false\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\r\n                <path d=\"M5 8L10 13L15 8\" stroke=\"var(--text)\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\r\n            <\/svg>\r\n            <\/div>\r\n    \r\n            <div class=\"trp-switcher-dropdown-list\"\r\n                 id=\"trp-shortcode-dropdown-6ac2ee6d8f28a\"\r\n                 role=\"group\"\r\n                 aria-label=\"Available languages\"\r\n                 hidden\r\n                 inert\r\n            >\r\n                                                            <a class=\"trp-language-item\" href=\"https:\/\/gmbay.com.tr\/en\/wp-json\/wp\/v2\/pages\/269#TRPLINKPROCESSED\" title=\"TR\">\r\n                                                                                        <span class=\"trp-language-item-name\" data-no-translation>TR<\/span>\r\n                                                                                <\/a>\r\n                                                <\/div>\r\n        <\/div>\r\n\r\n    <\/div>\r\n\n                    <\/div>\n                <\/li>\n            <\/ul>\n        <\/div>\n    <\/header>\n<\/div>\n\n<script>\n    const menuBtn = document.getElementById('gmbayMenuBtn');\n    const mobileDrawer = document.getElementById('gmbayMobileDrawer');\n\n    if (menuBtn && mobileDrawer) {\n        menuBtn.addEventListener('click', function() {\n            menuBtn.classList.toggle('is-active');\n            mobileDrawer.classList.toggle('is-open');\n        });\n    }\n\n    function toggleSubmenu(id, btn) {\n        const submenu = document.getElementById(id);\n        if (submenu) {\n            submenu.classList.toggle('sub-open');\n            const svg = btn.querySelector('svg');\n            if (svg) {\n                svg.style.transform = submenu.classList.contains('sub-open') ? 'rotate(180deg)' : 'rotate(0deg)';\n                svg.style.transition = 'transform 0.2s ease';\n            }\n        }\n    }\n<\/script>\n\n\n\n<!-- ITRAXYL - \u00dcR\u00dcN DETAY SAYfASI VE SSS -->\n<style>\n    \/* \u00dcr\u00fcn G\u00f6rsel Kutusu *\/\n    .detail-img-box {\n        background: linear-gradient(135deg, #ffffff 0%, #f8fafc 100%);\n        border: 1px solid rgba(226, 232, 240, 0.8);\n        border-radius: 2rem;\n        box-shadow: 0 10px 30px -4px rgba(4, 26, 51, 0.05);\n        padding: 3rem 2rem;\n        display: flex;\n        align-items: center;\n        justify-content: center;\n        position: relative;\n        overflow: hidden;\n    }\n    .detail-img-box::before {\n        content: '';\n        position: absolute;\n        top: -50%; left: -50%;\n        width: 200%; height: 200%;\n        background: radial-gradient(circle, rgba(139, 183, 69, 0.05) 0%, transparent 60%);\n        pointer-events: none;\n    }\n    .detail-img-box img {\n        max-width: 100%;\n        height: auto;\n        max-height: 450px;\n        object-fit: contain;\n        position: relative;\n        z-index: 10;\n        transition: transform 0.5s cubic-bezier(0.16, 1, 0.3, 1);\n    }\n    .detail-img-box:hover img {\n        transform: scale(1.08) translateY(-10px);\n    }\n\n    \/* Daha Okunakl\u0131 Teknik Detay Kutusu *\/\n    .specs-box {\n        background: #ffffff;\n        border: 1px solid #cbd5e1;\n        border-radius: 1.5rem;\n        box-shadow: 0 4px 20px -3px rgba(15, 23, 42, 0.05);\n    }\n    .specs-list li {\n        border-bottom: 1px solid #e2e8f0;\n        padding-bottom: 0.85rem;\n        margin-bottom: 0.85rem;\n        display: flex;\n        align-items: baseline;\n    }\n    .specs-list li:last-child {\n        border-bottom: none;\n        padding-bottom: 0;\n        margin-bottom: 0;\n    }\n\n    \/* S\u0131k\u00e7a Sorulan Sorular (Accordion) Stilleri *\/\n    .faq-details > summary {\n        list-style: none;\n    }\n    .faq-details > summary::-webkit-details-marker {\n        display: none;\n    }\n    .faq-details[open] summary ~ * {\n        animation: faqFadeIn 0.3s ease-in-out;\n    }\n    @keyframes faqFadeIn {\n        0% { opacity: 0; transform: translateY(-5px); }\n        100% { opacity: 1; transform: translateY(0); }\n    }\n    .faq-details[open] .faq-icon {\n        transform: rotate(180deg);\n        color: #8bb745;\n    }\n<\/style>\n\n<!-- \u00dcR\u00dcN DETAY \u0130\u00c7ER\u0130\u011e\u0130 -->\n<div class=\"py-12 md:py-20 bg-[#f8fafc] font-inter\">\n    <div class=\"max-w-6xl mx-auto px-4 sm:px-6 lg:px-8\">\n        \n        <!-- \u00dcst Geri D\u00f6n\u00fc\u015f Linki -->\n        <div class=\"mb-8 md:mb-10\">\n            <a href=\"https:\/\/gmbay.com.tr\/index.php\/urunlerimiz\/ilac-grubu\/\" class=\"inline-flex items-center gap-2 text-sm font-bold text-slate-500 hover:text-[#064f99] transition-colors\">\n                <svg class=\"w-4 h-4 rotate-180\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2.5\" d=\"M9 5l7 7-7 7\"><\/path><\/svg>\n                \u0130la\u00e7 Grubuna D\u00f6n\n            <\/a>\n        <\/div>\n\n        <div class=\"grid grid-cols-1 lg:grid-cols-12 gap-10 lg:gap-16 items-start mb-16\">\n            \n            <!-- SOL: B\u00dcY\u00dcK \u00dcR\u00dcN G\u00d6RSEL\u0130 -->\n            <div class=\"lg:col-span-5 relative\">\n                <div class=\"detail-img-box\">\n                    <img decoding=\"async\" src=\"https:\/\/gmbay.com.tr\/wp-content\/uploads\/2026\/08\/itraxyl.png\" alt=\"Itraxyl\">\n                <\/div>\n            <\/div>\n\n            <!-- SA\u011e: \u00dcR\u00dcN MET\u0130NLER\u0130 VE B\u0130LG\u0130LER\u0130 -->\n            <div class=\"lg:col-span-7 flex flex-col justify-center\">\n                \n                <!-- Kategori Rozeti -->\n                <span class=\"inline-flex items-center gap-1.5 text-xs font-bold tracking-widest text-[#064f99] bg-[#064f99]\/10 border border-[#064f99]\/20 px-3.5 py-1 rounded-full uppercase mb-4 w-max\">\n                    <span class=\"w-1.5 h-1.5 rounded-full bg-[#064f99]\"><\/span> \n                    \u0130la\u00e7 Grubu\n                <\/span>\n                \n                <!-- \u00dcr\u00fcn Ba\u015fl\u0131\u011f\u0131 -->\n                <h1 class=\"font-manrope text-3xl sm:text-4xl lg:text-5xl font-extrabold text-[#041a33] tracking-tight mb-5\">\n                    Itraxyl\n                <\/h1>\n                \n                <!-- Ana A\u00e7\u0131klama Metni -->\n                <div class=\"text-slate-700 text-base sm:text-lg font-normal leading-relaxed mb-8 space-y-4\">\n                    <p>\n                        \u0130trakonazol mantarlara kar\u015f\u0131 etki g\u00f6steren bir antifungaldir. \u0130trakonazol mantar h\u00fccresinin \u00e7evresinde bulunan zar\u0131n ge\u00e7irgenli\u011fini etkiler; h\u00fccre i\u00e7eri\u011finin h\u00fccre d\u0131\u015f\u0131na s\u0131zmas\u0131na yol a\u00e7ar.\n                    <\/p>\n                    <p>\n                        \u0130trakonazol a\u015fa\u011f\u0131daki durumlar ile ilgili bir ila\u00e7t\u0131r: akci\u011fer, a\u011f\u0131z, bo\u011faz, g\u00f6z, kad\u0131n d\u0131\u015f \u00fcreme organlar\u0131 ve vajina, s\u0131rt, eklemler, kemikler, ayak t\u0131rnaklar\u0131 veya el t\u0131rnaklar\u0131 gibi v\u00fccudun \u00e7e\u015fitli b\u00f6lgelerinde meydana gelen mantar enfeksiyonlar\u0131. \u0130trakonazol burada yer almayan di\u011fer tedavi edici ama\u00e7lar i\u00e7in de kullan\u0131l\u0131yor olabilir.\n                    <\/p>\n                <\/div>\n\n                <!-- Okunabilirli\u011fi Art\u0131r\u0131lm\u0131\u015f Teknik Bilgiler Kutusu -->\n                <div class=\"specs-box p-6 sm:p-8 mb-8\">\n                    <h3 class=\"font-manrope text-lg font-extrabold text-[#041a33] mb-5 flex items-center gap-2.5\">\n                        <div class=\"w-8 h-8 rounded-lg bg-[#064f99]\/10 text-[#064f99] flex items-center justify-center\">\n                            <svg class=\"w-4 h-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M9 12h6m-6 4h6m2 5H7a2 2 0 01-2-2V5a2 2 0 012-2h5.586a1 1 0 01.707.293l5.414 5.414a1 1 0 01.293.707V19a2 2 0 01-2 2z\"><\/path><\/svg>\n                        <\/div>\n                        \u00dcr\u00fcn Bilgileri\n                    <\/h3>\n                    \n                    <ul class=\"specs-list text-sm sm:text-base text-slate-700 font-medium space-y-2\">\n                        <li class=\"flex items-start gap-3\">\n                            <span class=\"text-[#064f99] font-bold mt-0.5\">\u2022<\/span>\n                            <span><strong class=\"font-bold text-[#041a33] min-w-[120px] inline-block\">\u00dcr\u00fcn:<\/strong> Itraxyl<\/span>\n                        <\/li>\n                        <li class=\"flex items-start gap-3\">\n                            <span class=\"text-[#064f99] font-bold mt-0.5\">\u2022<\/span>\n                            <span><strong class=\"font-bold text-[#041a33] min-w-[120px] inline-block\">Etken Madde:<\/strong> 100 mg itrakonazol<\/span>\n                        <\/li>\n                        <li class=\"flex items-start gap-3\">\n                            <span class=\"text-[#064f99] font-bold mt-0.5\">\u2022<\/span>\n                            <span><strong class=\"font-bold text-[#041a33] min-w-[120px] inline-block\">Ticari \u015eekli:<\/strong> 4 \/ 15 \/ 28 kaps\u00fcl<\/span>\n                        <\/li>\n                    <\/ul>\n                <\/div>\n\n                <!-- Aksiyon Butonlar\u0131 (PDF Linkleri) -->\n                <div class=\"flex flex-col sm:flex-row flex-wrap items-center gap-3\">\n                    <a href=\"https:\/\/gmbay.com.tr\/kt\/itraxyl_kullanim_talimati.pdf\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"w-full sm:w-auto inline-flex items-center justify-center gap-2 bg-[#8bb745] text-white font-bold text-sm px-6 py-3.5 rounded-xl hover:bg-[#76a035] transition-colors shadow-md shadow-[#8bb745]\/20\">\n                        <svg class=\"w-5 h-5\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M12 10v6m0 0l-3-3m3 3l3-3M3 17V7a2 2 0 012-2h6l2 2h6a2 2 0 012 2v8a2 2 0 01-2 2H5a2 2 0 01-2-2z\"><\/path><\/svg>\n                        Kullan\u0131m Talimat\u0131\n                    <\/a>\n                    <a href=\"https:\/\/gmbay.com.tr\/kt\/itraxyl_kisa_urun_bilgisi.pdf\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"w-full sm:w-auto inline-flex items-center justify-center gap-2 bg-white text-[#064f99] border border-[#064f99] font-bold text-sm px-6 py-3.5 rounded-xl hover:bg-[#064f99]\/5 transition-colors shadow-sm\">\n                        <svg class=\"w-5 h-5\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M9 12h6m-6 4h6m2 5H7a2 2 0 01-2-2V5a2 2 0 012-2h5.586a1 1 0 01.707.293l5.414 5.414a1 1 0 01.293.707V19a2 2 0 01-2 2z\"><\/path><\/svg>\n                        K\u0131sa \u00dcr\u00fcn Bilgisi\n                    <\/a>\n                <\/div>\n\n            <\/div>\n        <\/div>\n\n        <!-- SIK\u00c7A SORULAN SORULAR B\u00d6L\u00dcM\u00dc -->\n        <div class=\"mt-16 md:mt-24 max-w-4xl mx-auto\">\n            <div class=\"text-center mb-10\">\n                <h2 class=\"font-manrope text-2xl sm:text-3xl font-extrabold text-[#041a33] tracking-tight\">S\u0131k\u00e7a Sorulan Sorular<\/h2>\n                <div class=\"w-16 h-1 bg-[#8bb745] mx-auto mt-4 rounded-full\"><\/div>\n            <\/div>\n\n            <div class=\"space-y-3\">\n                \n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Itraxyl\u2019in karaci\u011fer fonksiyonlar\u0131 \u00fczerine olumsuz etkileri var m\u0131d\u0131r?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Itraxtyl\u2019in etken maddesi olan \u0130trakonazol\u2019\u00fcn \u00f6zellikle dermatolojik mantar enfeksiyonlar\u0131nda klasik tedavi yakla\u015f\u0131m\u0131 ile uzun s\u00fcreli kullan\u0131m\u0131ndan dolay\u0131 bu tip endi\u015feler ya\u015fanabilmektedir. Ancak, Itraxyl\u2019in K\u00fcr tedavi uygulanmas\u0131 ile karaci\u011fer \u00fczerine olumsuz etkileri yoktur. 2002 y\u0131l\u0131nda yap\u0131lan bir klinik \u00e7al\u0131\u015fmada, Itrakonazol\u2019\u00fcn (K\u00fcr) Pulse tedavi uygulanan hastalar\u0131n AST, ALT, Alkalin Fosfataz ve Total Bilirub\u00fcn testleri izlenmi\u015ftir. \u0130trakonazol, karaci\u011fer \u00fczerine etkileri a\u00e7\u0131s\u0131ndan g\u00fcvenli bulunmu\u015ftur.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Itraxyl ya\u015fl\u0131larda kullan\u0131l\u0131r m\u0131?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Polifarmasi yani birden fazla ila\u00e7 uygulanan ya\u015fl\u0131larda \u0130trakonazol\u2019\u00fcn ila\u00e7 etkile\u015fimlerinden dolay\u0131 bu tip sorular al\u0131nabilmektedir. Itraxyl\u2019in ya\u015fl\u0131larda kullan\u0131lmas\u0131 ile ilgili herhangi bir sak\u0131nca yoktur. \u0130trakonazol\u2019\u00fcn ya\u015fl\u0131larda kullan\u0131m\u0131na uygunlu\u011fu ve etkinli\u011fi hakk\u0131nda yap\u0131lm\u0131\u015f olan klinik \u00e7al\u0131\u015fmalar da mevcuttur. Ya\u015fl\u0131larda \u0130trakonazol etkili ve g\u00fcvenilirdir.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        K\u00fcr tedavisi nas\u0131l uygulan\u0131r? K\u00fcr tedavisi neden tercih edilmeli?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        \u0130trakonazol dokuya yerle\u015ftikten sonra at\u0131l\u0131m\u0131, dokunun kendisini yenilemesi ile olur. \u0130trakonazol y\u00fcksek Keratinofilik ve Lipofilik \u00f6zellikleri sayesinde, hedef dokuda uzun s\u00fcre kalarak k\u00fcr tedavisine olanak sa\u011flar. K\u00fcr (Pulse) Tedavi: \u0130trakonazol\u2019un uzun s\u00fcreli dokularda kalmas\u0131ndan dolay\u0131 hem toplamda al\u0131nan ila\u00e7 miktar\u0131n\u0131 hem de maliyeti azaltan tedavi \u015feklidir. Bir k\u00fcrl\u00fck tedavi bir hafta boyunca g\u00fcnde 2&#215;2 (400mg\/g\u00fcn) doz ila\u00e7 kullan\u0131m\u0131ndan sonra 3 hafta ara verilmesi \u015feklinde uygulan\u0131r. \u00d6zellikle Onikomikoz gibi dermatolojik mantar enfeksiyonlar\u0131nda uzun s\u00fcren ve karaci\u011fer enzimlerinin takibini gerektiren klasik tedavi yakla\u015f\u0131m\u0131 yerine, tetkik zorunlulu\u011funu da ortadan kald\u0131ran \u0130trakonazol k\u00fcr tedavisinin uygulanmas\u0131 sayesinde daha az ve daha k\u0131sa s\u00fcreli ila\u00e7 kullan\u0131m\u0131 ile etkin ve g\u00fcvenilir tedavi sa\u011flan\u0131r.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Onikomikoz tedavisinde Terbinafin ve \u0130trakonazol etkinli\u011fini kar\u015f\u0131la\u015ft\u0131r\u0131r m\u0131s\u0131n\u0131z?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Enfekte dokuda uzun s\u00fcre terap\u00f6tik konsantrasyonda kalan antifungal ajan, etkili tedavi sa\u011flar. \u0130trakonazol t\u0131rnak dokusunda 9 ay kal\u0131rken, Terbinafin ancak 6 ay kalabilmektedir. Ayr\u0131ca yap\u0131lan bir klinik \u00e7al\u0131\u015fmaya g\u00f6re Onikomikoz tedavisinde \u0130trakonazol k\u00fcr tedavisi ile tedavi edilen hastalarda klinik iyile\u015fme oran\u0131 %77 iken 3 ay boyunca her g\u00fcn 250 mg Terbinafin kullanan hastalarda bu oran ancak %68 olabilmi\u015ftir. Ayr\u0131ca ayn\u0131 \u00e7al\u0131\u015fmaya ba\u011fl\u0131 olarak ya\u015fanan yan etkiler nedeni ile hastalar\u0131n tedaviyi b\u0131rakma oran\u0131 Terbinafin kullanan hastalarda %12 iken \u0130trakonazol grubunda hi\u00e7bir hasta tedaviyi b\u0131rakmam\u0131\u015ft\u0131r.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Terbinafin\u2019in ila\u00e7 etkile\u015fimleri nas\u0131ld\u0131r?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        \u0130n-vitro \u00e7al\u0131\u015fmalar Terbinafin\u2019in CYP2D6 (Sitokrom P450 2D6) ili\u015fkili metabolizmay\u0131 inhibe etti\u011fini g\u00f6stermi\u015ftir. \u0130la\u00e7lar\u0131n yakla\u015f\u0131k %25\u2019inin oksidatif metabolizmas\u0131ndan sorumlu Sitokrom P450 enzimi CYP2D6\u2019d\u0131r. CYP2D6, terap\u00f6tik indeksi dar ve dolay\u0131s\u0131yla ila\u00e7 tedavisinin yetersiz kalmas\u0131na ya da toksik reaksiyonlar\u0131n daha kolay ortaya \u00e7\u0131kmas\u0131na neden olabilecek bir\u00e7ok ilac\u0131n metabolizmas\u0131nda rol oynamaktad\u0131r. Bu enzim taraf\u0131ndan metabolize edilen trisiklik antidepresanlar, beta blokerler, SSRI (se\u00e7ici seratonin geri al\u0131m inhibit\u00f6rleri) ile beraber terbinafin kullan\u0131lmas\u0131 durumunda dikkat edilmesi gerekmektedir. G\u00f6r\u00fcld\u00fc\u011f\u00fc gibi Terbinafin ile etkile\u015fime giren ila\u00e7lar \u00fclkemizde \u00e7ok yayg\u0131n kullan\u0131lmaktad\u0131r. Ayr\u0131ca Terbinafin dermatolojik mantar hastal\u0131klar\u0131n\u0131n tedavisinde s\u00fcrekli tedavide kullan\u0131l\u0131r. Tedavi s\u00fcresi uzun olan ila\u00e7 kullan\u0131m\u0131 s\u00fcresi i\u00e7erisinde polifarmasi yani \u00e7ok say\u0131da ila\u00e7 uygulanan hastalar\u0131n dikkatli takipleri gerekmektedir.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Oral kandiyazis tedavisinde Itraxyl nas\u0131l kullan\u0131l\u0131r?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Oral kandiyazis tedavisinde Itraxyl 15 g\u00fcn boyunca g\u00fcnde 1 kez 100mg pozolojisi ile kullan\u0131lmal\u0131d\u0131r.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Antiasit ve PPI grup ila\u00e7larla beraber Itraxyl nas\u0131l kullan\u0131lmal\u0131d\u0131r?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Mide asidi azald\u0131\u011f\u0131nda \u0130trakonazol\u2019\u00fcn emilimi de azal\u0131r. Itraxyl\u2019in, antiasit ve PPI (proton pompa inhibit\u00f6r\u00fc) grubu ila\u00e7lar gibi mide asiditesini azaltan ila\u00e7larla beraber kullan\u0131lmas\u0131 gerekiyorsa bu ila\u00e7lar\u0131n Itraxyl al\u0131nmas\u0131ndan en az 2 saat sonra al\u0131nmas\u0131 \u00f6nerilmektedir.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Hamileler Itraxyl kullanabilir mi?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        \u0130trakonazol\u2019\u00fcn gebe kad\u0131nlarda kullan\u0131m\u0131 hakk\u0131nda yap\u0131lm\u0131\u015f bir \u00e7al\u0131\u015fma yoktur. Itraxyl\u2019in gebelik kategorisi C\u2019dir. Do\u011furganl\u0131k \u00e7a\u011f\u0131ndaki kad\u0131nlarda, \u0130trakonazol tedavi bitiminden itibaren bir sonraki menstruel d\u00f6nemine kadar, uygun kontraseptif y\u00f6ntemler kullan\u0131lmal\u0131d\u0131r. Gebe kad\u0131nlarda sadece hayat\u0131 tehdit eden sistemik mikozlarda, elde edilebilecek yarar\u0131n fetusa olas\u0131 risklerin \u00fczerinde oldu\u011fu durumlarda hekim karar\u0131na g\u00f6re kullan\u0131lmas\u0131 \u00f6nerilebilir.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Itraxyl kullan\u0131m\u0131 s\u00fcresince hasta takibi gerekli midir?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Itraxyl k\u00fcr tedavisi ile tedavi edilen hastalarda hasta takibi gerekli de\u011fildir. Terbinafin ile s\u00fcrekli tedavi uygulanan hastalarda, 4-6 hafta ara ile tam kan say\u0131m\u0131 ve karaci\u011fer enzim testleri olan AST, ALT d\u00fczeylerinin izlenmesine ihtiya\u00e7 vard\u0131r.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Itraxyl\u2019in geni\u015f etki spektrumlu olmas\u0131 neden \u00f6nemlidir?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Hem jinekolojik hem dermatolojik mantar enfeksiyonlar\u0131nda patojeni tespit etmek genellikle zordur. Patojenin tespit edilemedi\u011fi durumlarda geni\u015f etki spektrumu ile Itraxyl ilk tercih edilecek tedavi ajan\u0131d\u0131r. Itraxyl\u2019in geni\u015f etki spektrumu sayesinde mikst enfeksiyonlarda etkin tedavi sa\u011flar.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Itraxyl\u2019in \u00e7ocuk hastalarda ba\u015flang\u0131\u00e7 ya\u015f\u0131 ka\u00e7t\u0131r?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        \u0130trakonazol\u2019\u00fcn \u00e7ocuklarda kullan\u0131m\u0131 ile ilgili klinik \u00e7al\u0131\u015fmalar s\u0131n\u0131rl\u0131 oldu\u011fundan, sa\u011flanabilecek yarar, potansiyel riskin \u00fczerinde olmad\u0131k\u00e7a \u00e7ocuklarda kullan\u0131lmas\u0131 \u00f6nerilmez. Hekimin gerekli g\u00f6rd\u00fc\u011f\u00fc durumlarda uygulanan baz\u0131 pediatrik g\u00fcnl\u00fck doz uygulamalar\u0131na dair bilgiler literat\u00fcrlerde belirtilmi\u015ftir.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Itraxyl ile jinekolojik mantar hastal\u0131klar\u0131n\u0131n tedavisinde e\u015f tedavisi gerekli midir?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Vajinal kandiaziste e\u015f tedavisine gerek yoktur. Jinekolojik mantar enfeksiyonlar\u0131n\u0131n tedavisinde e\u015f tedavisi uygulamas\u0131 klinik \u00e7evrelerce desteklenen bir durum de\u011fildir. Jinekolojik mantar enfeksiyonlar\u0131n\u0131n as\u0131l bula\u015f yolu cinsel ili\u015fkiden ziyade ki\u015finin normal floras\u0131 ve gastrointestinal sistemdir. Itraxyl ile jinekolojik mantar hastal\u0131klar\u0131n\u0131n tedavisinde e\u015f tedavisine gerek yoktur. Fakat tedaviyi uygulayacak olan hekimin hastas\u0131n\u0131n durumuna g\u00f6re e\u015f tedavisini uygulayabilmektedir.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Kronik ve tekrarlay\u0131c\u0131 jinekolojik mantar enfeksiyonlar\u0131nda Itraxyl kullan\u0131labilir mi?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Yap\u0131lan klinik \u00e7al\u0131\u015fmalar \u0130trakonazol\u2019\u00fcn kronik ve tekrarlay\u0131c\u0131 jinekolojik mantar enfeksiyonlar\u0131nda etkili oldu\u011funu kan\u0131tlamaktad\u0131r. Yap\u0131lan bu klinik \u00e7al\u0131\u015fmalar i\u00e7erisinde farkl\u0131 tedavi protokolleri uygulanabilmekle birlikte genel olarak ba\u015flang\u0131\u00e7 dozu bir g\u00fcn 2&#215;2 ard\u0131ndan profilaksi amac\u0131 ile 6 ay s\u00fcre ile her menstr\u00fcel siklusun birinci g\u00fcn\u00fc, g\u00fcnde 2&#215;2 \u015feklinde kullan\u0131m\u0131 \u00f6nerilmektedir. 6 ay s\u00fcre ile uygulanan bu tedavi \u015fekli sonunda \u0130trakonazol\u2019\u00fcn kronik ve tekrarlay\u0131c\u0131 vajinal mantar enfeksiyonlar\u0131nda %85\u2019e varan klinik ve mikolojik iyile\u015fme sa\u011fland\u0131\u011f\u0131 g\u00f6zlenmi\u015ftir. Bu \u00e7al\u0131\u015fmalar kronik ve tekrarlay\u0131c\u0131 vajinal mantar enfeksiyonlar\u0131nda \u0130trakonazol kullan\u0131m\u0131 desteklemektedir. \u0130trakonazol i\u00e7eren \u00fcr\u00fcnlerin onayl\u0131 prospekt\u00fcslerinde konuyla ilgili bir pozoloji bulunmamaktad\u0131r. Kronik ve tekrarlay\u0131c\u0131 vajinal mantar enfeksiyonlar\u0131nda \u0130trakonazol\u2019\u00fcn etkinli\u011fini soran hekimlere literat\u00fcr \u0131\u015f\u0131\u011f\u0131nda bu bilimsel verileri aktarabiliriz.\n                    <\/div>\n                <\/details>\n\n                <details class=\"faq-details group bg-white border border-slate-200 rounded-xl overflow-hidden shadow-sm\">\n                    <summary class=\"cursor-pointer p-5 sm:px-6 font-bold text-[#041a33] text-sm sm:text-base flex justify-between items-center hover:bg-slate-50 transition-colors\">\n                        Mikst vajinal enfeksiyonlar\u0131n tedavisinde, \u0130trakonazol ve Ornidazol nas\u0131l tercih edilmelidir?\n                        <svg class=\"faq-icon w-5 h-5 text-slate-400 transition-transform duration-300 flex-shrink-0 ml-4\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"><path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19 9l-7 7-7-7\"><\/path><\/svg>\n                    <\/summary>\n                    <div class=\"p-5 sm:px-6 pt-0 text-slate-600 font-light text-sm sm:text-base leading-relaxed border-t border-slate-100 mt-2\">\n                        Mikst enfeksiyonlar; bakteriler, protozoalar ve mantarlar gibi birden fazla patojenin bir arada bulundu\u011fu enfeksiyonlard\u0131r. Ornidazol ve Itrakonazol\u2019\u00fcn birlikte kullan\u0131lmas\u0131 gereken durumlarda; \u0130trakonazol\u2019\u00fcn 1 g\u00fcn (2&#215;2) vulvovajinal kandiyazis pozolojisinde belirtildi\u011fi \u015fekilde; beraberinde Ornidazol\u2019\u00fcn ise 5 g\u00fcnl\u00fck tedavi \u015feklinde (2&#215;1) uygulanmas\u0131, genel kabul g\u00f6ren uygulama \u015feklidir.\n                    <\/div>\n                <\/details>\n\n            <\/div>\n        <\/div>\n\n    <\/div>\n<\/div>\n\n\n\n<!-- 7. 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"disabled","ast-banner-title-visibility":"disabled","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"disabled","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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